Having too much liver fat is known as nonalcoholic fatty liver disease. The researchers report online in the journal Proceedings of the National Academy of Sciences (Early Edition) that when fat collects in the liver, people experience serious metabolic problems such as insulin resistance, which affects the body's ability to metabolize sugar. They also have increases in production of fat particles in the liver that are secreted into the bloodstream and increase the level of triglycerides.
"We don't know exactly why some fats, particularly triglycerides, will accumulate inside the liver and muscle in some people but not in others," says first author Elisa Fabbrini, M.D., Ph.D., assistant professor of medicine. "But our data suggest that a protein called CD36, which controls the transport of fatty acids from the bloodstream into different tissues, is involved."
Senior Investigator, Samuel Klein, M.D., says those who are obese but don't have high levels of fat in the liver should be encouraged to lose weight, but those with elevated liver fat are at particularly high risk for heart disease and diabetes. He says they need to be treated aggressively to help them lose weight because dropping pounds can make a big difference.
"Fatty liver disease is completely reversible," he says. "If you lose a small amount of weight, you can markedly reduce the fat content in your liver.
Summary from article: Fat in the Liver, ScienceDaliy.com, Aug 25, 2009
Other related articles:
http://www.sciencedaily.com/releases/2011/04/110406102135.htm http://www.sciencedaily.com/releases/2009/08/090824151304.htm
"We don't know exactly why some fats, particularly triglycerides, will accumulate inside the liver and muscle in some people but not in others," says first author Elisa Fabbrini, M.D., Ph.D., assistant professor of medicine. "But our data suggest that a protein called CD36, which controls the transport of fatty acids from the bloodstream into different tissues, is involved."
Senior Investigator, Samuel Klein, M.D., says those who are obese but don't have high levels of fat in the liver should be encouraged to lose weight, but those with elevated liver fat are at particularly high risk for heart disease and diabetes. He says they need to be treated aggressively to help them lose weight because dropping pounds can make a big difference.
"Fatty liver disease is completely reversible," he says. "If you lose a small amount of weight, you can markedly reduce the fat content in your liver.
Summary from article: Fat in the Liver, ScienceDaliy.com, Aug 25, 2009
Other related articles:
http://www.sciencedaily.com/releases/2011/04/110406102135.htm http://www.sciencedaily.com/releases/2009/08/090824151304.htm